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| Protective Effects of Fullerenol in 60Coγ-Ray Irradiated Mice |
| SUN Ding, GAO Fu, CUI Jian-Guo, et al |
| Department of Radiation Medicine, Faculty of Navy Medicin, Second Military Medical University, Shanghai 200433 China |
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Abstract Objective To investigate the protective effects of fullerenol in ICR mice against 60Coγ-ray.radiation.Methods ICR mice were injected (ip)with fullerenol continuously from 5d before to 7d after whole-body 60Coγ-ray irradiation.The total dose was 5.0Gy and 8.0Gy respectively and the dose rate was 1.0 Gy/min.The change in body weight and index of spleen,index of thymus,peripheral blood cell counts on the 7th day after irradiation were observed.The survival rate and average survival time were monitored during the period of 30 days after irradiation.Result Fullerenol showed significant radioprotective effects on white blood cell and platelet counts,protecting spleen and thymus.Also fullerenol increased the survival rate on the 30th day after irradiation and the average survival time.Conclusion Fullerenol has efficient capacity of radioprotection in irradiated mice.
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Received: 10 September 2009
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