SHAO Qian, LIU Shan-shan, LI Jian-bin, WANG Wei, ZHANG Ying-jie, LI Feng-xiang
2017, 26(3): 372-377.
Objective The aim of the present study was to analyse clinical data obtained from patients with Ⅳ stage lung cancer, including the initial clinical symptoms upon diagnosis, the types of pathological classification, transferred organs, treatment strategy and prognosis.Methods A retrospective analysis was conducted of the clinical features of 539 lung cancer patients(Ⅳ stage) who were initially diagnosed and treated at Shandong Cancer Hospital and Institute (Jinan, China) in 2009. the clinical features of 539 cases of patients,including male 351 cases(65.1%), female 188 cases (34.9%).The maximum and minimum age were 88 and 19 years old, respectively.The average age was 58.51and the median age was 59, but the age less than 60 years old was 282 cases (52.3%).The main symptoms were cough, sputum, blood in phlegm, chest pain, chest tightness, holding breath, fever and extrapulmonary symptoms. The types of cytology and/or pathological such as adenocarcinoma, squamous carcinoma, small cell carcinoma, large cell carcinoma, adenosquamous carcinoma and other types were respectively 377 cases (69.9%), 95 cases (17.6%), 50 cases (9.3%), 9 cases (1.7%), 5 cases (0.9%) and 3 cases (0.6%).The metastases from one single organ and multiple organs were 393 cases (72.9%), 146 cases (27.1%), respectively. Single organ metastasis such as pleura, brain, bone, lung, liver, adrenal metastasis is respectively 112 cases (28.5%), 100 cases (25.4%), 78 cases (19.8%), 60 cases (15.3%), 29 cases (7.4%), 14 cases (3.6%). The Kaplan Meier method and multivariate Cox regression analysis were performed to analyse the influence of age, predominant symptoms, pathological classification, transferred organs, treatment strategy on patient's overall survival.Results The 1, 2 and 3 year survival rates were 64.2% (346 cases), 19.7% (106 cases) and 1.5% (8 cases),respectively. The metastases of liver and pleura were poor prognosis, but the bone metastases were relatively well. Multi-factor analysis showed that the patient's age, different metastatic organs, The number of metastatic organs and treatment were independent risk factors on survival.Conclusion The clinical symptoms of patients with Ⅳ stage lung cancer are diversiform and have no specificity. The prognosis is poor. The patient's age, different metastatic organs, the number of metastatic organs, and treatment affect patient's survival.