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  • 28 September 2012 Volume 21 Issue 3
      
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  • Effects of BSH on the Proliferation of Cells Irradiated by γ-Ray
    QIAN Tian-tian, HE Ying, WANG Qing-rong, CHEN Wei, SHEN Xian-rong
    2012, 21(3): 257-259. https://doi.org/10.13491/j.cnki.issn.1004-714x.2012.03.023
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    Objective To study the protective effect of BSH on the proliferation of Hela and HIEC cells irradiated by γ-ray. Methods Hela and HIEC cells which were given BSH,were exposed to 137Cs γ-ray one time with the different doses (1, 2, 3, 4, 6, 8 Gy) at the dose rate of 0.8 Gy/min. The proliferation of cells were measured by MTT assay and cell clone formation assay. Results MTT assay showed that BSH has a significant protective effect on cells at the concentration of 0.0036 mg/ml to 0.1150 mg/ml. Clone formation assay showed that the protective effect of BSH (0.060mg/ml) was different when cells exposed to different doses. Conclusion BSH can increase proliferation of Hela and HIEC cells irradiated by γ-ray.
  • Protective Effects of Radaway Radioprotection Capsule on Radition Injured Mice
    ZHAO Cui-Xia, YUAN Xue-Fen, SUN Li, WANG Xiao-Dan, XIE Tao
    2012, 21(3): 259-260. https://doi.org/10.13491/j.cnki.issn.1004-714x.2012.03.024
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    Objective To observe the protective effects of Radaway radioprotection capsule on radition injured mice. Methods 120 female Kunming mice were randomly divided into 3 groups by the processing as peripheral white blood cell count(group I), marrow cell micronuclei detection(group Ⅱ), and bone marrow DNA count(group Ⅲ). And for each group, mice were further partitioned into low,middle and high dosage groups and radiation control group. The mice were all exposed by 3Gy radiation. Results The peripheral white blood cell level on the 14th day after radiation in three dose groups were all significantly higher than that of radiation control group. On the 3rd day after radiation,comparing with radiation control group micronucleus rate of marrow cells in middle and low dose groups was significantly lower,DNA count in bone marrow in low dose group was significantly higher. Conclutions Radaway radioprotection capsule has significantly protective effects on γ-ray radiation injuries of mice.
  • Clinical Investigation Study on Occupational Exposure of Operators During Cardiovascular Intervention
    DING Yan-qiu, SUN Jing-xing, JIAO Ling, FENG Xin, ZHANG Xiao-dong, ZHANG Zhong-jian, WU Quan, ZHANG Wen-yi
    2012, 21(3): 261-263. https://doi.org/10.13491/j.cnki.issn.1004-714x.2012.03.025
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    Objective To investigate the personal effective dose of the operator in cardiovascular intervention. Methods Lithium fluoride (LiF) thermoluminescent dosimeters (TLD) were used to carry out personal dose monitoring for the operator. Effective doses of the operator were evaluated in 28 clinical operations. Results The average fluoroscopy time for 24 Coronary angiography (CA), percutaneous transluminal coronary angioplasty (PTCA) and percutaneous intracoronary arterial stenting (PICAS) procedures was 19.2 ±6.3 min, and the average effective dose of the operator per procedure was 4.1 ±0.9μSv (under protection) and 52.2 ±15.5 μSv (without protection). However, for 4 PT procedures, average fluoroscopy time was 14.1 ±4.6 min, and the average effective dose of the operator per operation was 5.5 ±1.4 μSv (under protection) and 220 ±42 μSv (without protection). Conclusions Reducing fluoroscopy time, femoral artery access to the patients are recommended during interventional procedures. In order to decrease the radiation risk to the lowest level, more advanced equipments should be applied and radiation protection should be fully managed.
  • Monitoring and Analysis PET/CT Workplace Radioactivity Level in Shanghai
    WANG Bin, GAO Lin-feng, QIAN Ai-jun, YAO Jie, SHEN Jin-fu, JI Gui-yi
    2012, 21(3): 263-265. https://doi.org/10.13491/j.cnki.issn.1004-714x.2012.03.026
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    Objective To understand the PET/CT basic information in Shanghai, through monitoring radioactivity level of PET/CT workplace, to get the radiological protection information about PET/CT place. Methods Through the γ radiation air absorbed dose rate and the β surface contamination to investigate PET/CT medical institutions in Shanghai. Results By the end of 2011, there were 13 sets of PET/CT. Detecting show that γ radiation air absorbed dose rate is at relatively higher level in waiting room and the injection rooms, the date of waiting room door was up to 19 552 nSv/h, the maximum value of injection room desk surface was 6 136 nSv/h, the middle of injection room was up to 5 408 nSv/h. Any date was certain the limits of national standard of β surface contamination, the middle of in the injection room. It is still higher on the window and wastes barrel. Conclusion The radiation protection of PET/CT workplace is proper, surface contamination levels can be contralled within in the standard limits, but there are a blank of limits about nuclear medicine place of γ radiation absorbed dose rate air in the national standard, and external exposure protection is still the key of radiation protection.
  • Inhibitive Effects of 17act-D-homo Ethynylestradiol-3-acetate in Tumor-bearing Mice
    HAN Ying, SONG Na-ling, WANG Yue-ying, SUN Yuan-ming, WU Hong-ying, LI De-guan
    2012, 21(3): 266-267. https://doi.org/10.13491/j.cnki.issn.1004-714x.2012.03.065
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    Objective To observe the inhibitory effect of 17act-D-homo ethynylestradiol-3-acetate combined 137Cs radiation in leukemia L1210 cells. Methods The animal model of leukemia (L1210) was prepared by tumor cell inoculation. All animal divided into six groups, control group, group treated only with radiation, 17act-D-homo ethynylestradiol-3-acetate high-level group, 17act-D-homo ethynylestradiol-3-acetate mid-level group, 17act-D-homo ethynylestradiol-3-acetate low-level group and group combined E838 and radiation. Mice with leukemia (L1210) followed intraperitoneal injection of 17act-D-homo ethynylestradiol-3-acetate once a day for 7 days. Tumor inhibition rate, the number of bone marrow nucleated cells, thymus index and spleen index were detected at the fifth day after the last administration and compare the difference in different groups. Results Tumor in every groups treated with 17act-D-homo ethynylestradiol-3-acetate significant smaller than the control. 17act-D-homo ethynylestradiol-3-acetate combined radation has great inhibition effect in tumor-bearing mice (L1210). Conclusion 17act-D-homo ethynylestradiol-3-acetate has significant inhibition effect in leukemia (L1210) and could protect the immune organs in mice. 17act-D-homo ethynylestradiol-3-acetate combined radiation could enhance the anti-tumor therapy.
  • Testing and Analysis on Total Protein, Albumin, Globulin and A/G of Salivary in Radiation Exposure Persons
    WANG Jun, LI Guang-wen, LI Gang, LI Hui, ZHANG Yan, GUO Jing, WANG Yu-xin, LI Cui-xia
    2012, 21(3): 268-270. https://doi.org/10.13491/j.cnki.issn.1004-714x.2012.03.016
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    Objective To study the oral health effect of long term low dose radiation on exposure personnel and to provide a basis for further improving the protection ability. Methods Testing method, which was based on APT and HSA interactions induced by synchronous fluorescence specific changes, and intensity and concentrations of HSA in the solution in the system of synchronous fluorescence showed a good linear relations. The establishment of a APT as a molecular probe was used to test concentration of salivary total protein (TP), albumin(ALB), globulin (GL0) and albumin by synchronous fluorescence spectrum analysis. The information was analyzed in Foxpro 6.0 and SPSS 16.0 software. Result Protein(TP) Mean Value was 3.904 ±1.369g/L g/L,Minimum Value was 0.30 g/L and Maximum Value was 7.50g/L. Albumin (ALB) Mean Value was 0.965 ±0.665g/L,Minimum Value was 0.09 g/L and Maximum Value was 3.98g/L. Globulin (GLO) Mean Value was 2.895 ±0.947g/L,Minimum Value was 0.01g/L and Maximum Value was 5.81g/L. A/G Mean Value was 0.327. Conclusion Long term and low dose of radiation would break the chronic physiological balance and concentration of salivary total protein (TP), albumin(ALB), globulin (GL0) and albumin and globulin ratio (A/G) changed obviously. It was necessary to do more special oral health care, further improve the individual protection consciousness, strengthen the radiation monitoring and protection measures, improve the regulation system, and reduce radiation damage on special personnel health significantly.