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  • 28 August 2013 Volume 22 Issue 4
      

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  • JV Yong-jian, WANG Gao-ren, CAO Li-yuan, LI Ke-xin, WU Di-jun, TANG Ya-hong
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    Objective To analyze the dosimetric differences between the results calculated from the PBC algorithm and AAA algorithm respectively in the intensity-modulated radiotherapy(IMRT) treatment planning design for the prostate cancer patients. Methods For 13 postoperative prostate cancer patients, when the IMRT treatment plan was designed, the dose parameters were calculated with PBC algorithm and AAA algorithm respectively which was provided by the treatment planning system(Eclipse Version 8.10), then the dosimetric parameters, such as HI,CI,PTVDP,PTVmean,and the V50 of bladder and rectum were obtained and compared respectively. We also do the dose verification measurement with the two-dimensional ionization chamber array, and the actual measured dose distribution will be compared with that calculated from the AAA and PBC algorithm respectively to obtain the γ value, the dose difference in measurement chamber matrix point, DDmax and DD mean. Results The average difference of HI,CI,PTVDP and PTVmean between the results calculated with PBC and AAA algorithm separately are 0.003、0.004、2.2%、10 cGy respectively, and the average difference of bladder V50 and rectum V50 are 0.3% and 1.3%. Compared the dosimetric result calculated from the above mentioned two algorithms with the measurement result, the average difference of γ value, DDmax and DDmean are 0.9%、1.2% (2.4 cGy) and 0.85% (1.7 cGy) respectively. So the dose parameters calculated from the AAA and PBC algorithms are trivial. Conclusion For the prostate cancer patients IMRT treatment planning design, the PBC algorithm and AAA algorithm can all be used.
  • LIU Wei-wei, LI Jun, WANG Guang-li, WANG Zhong-zhou, LUO Yi
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    Objective To study comparatively the imaging quality and radiation doses between VolumeRAD and CT in order to chose appropriate X-ray examination method for clinic. Methods To get VolumeRAD and CT images by the module and recorded each radiation doses. Results Low contrast resolutions were 4 mm,7 mm and 0 mm when contrast were 1%, 0.5% and 0.3% respectively, and high contrast resolution was 9 lp/cm and radiation dose was 1.26 mGy in VolumeRAD, while in CT, low contrast resolutions were 2 mm,4 mm and 6 mm when contrast were 1%,0.5% and 0.3% respectively and high contrast resolution was 7 lp/cm and radiation dose was 28 mGy. Conclusion VolumeRAD overcomes the overlaying structures of body tissues in DR and possesses higher high contrast resolution and lower low contrast resolution and much lower radiation dose compared with CT, which has economic,simple and high diagnostic value features.
  • HUANG Ming, ZHANG Hui, KANG Ning, HU Yu-xin, WANG Bing, DENG Yan-li
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    Objective To study the long-term stability parameter of energy-store of TLD 2000C thermoluminescence dosimeter(TLD), gain the attenuation law of the energy-store of this type of TLD by storage time after irradiation, and determine the largest storage time after irradiation. Methods Performance experiment is done at normal environment in Beijing, Dalian and Shenzhen for 12 months to analyze the long-term stability of energy-store of TLD. Results With the increase of storage time, the attenuation of energy-store of TLD is also increased. Conclusion The degree of attenuation of energy-storage of TLD is less than 10% for 6 months storage after irradiation, and the period of personal dose monitoring could be extended to 6 months only from the perspective of energy-storage capacity of TLD. Forther more the time between the anneal and measurement of TLDs should be shorter than 6 months.
  • PAN Xiang, LIN Zhi-kai, PAN Jun-feng
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    Objective In order to acquaint the protective effects of 5% (atomic number%) borated polyethylene shielding fast neutron, Experimental studies of protective effects were carried out respectively using californium-252(252Cf) and americium-beryllium(241Am-Be) standard neutron sources for its protective effects against fast neutron. Methods To cut the 5% borated polyethylene of thickness 3.2 cm into the circular samples of diameter 5.5 cm thickness 3.2 cm, then to overlay them into samples of different thickness, after that to determine the fast neutron transmission rate of the different thickness borated polyethylene plates irradiated by 252Cf and 241Am-Be standard neutron sources in Primary Metrology Station of Industry for National Defense Science and Technology. Results The results show that the neutron shielding effects are 47.7% and 60% respectively for 241Am-Be and 252Cf neutron sources when thickness of The borated polyethylene plate is 3.2 cm; The neutron shielding effects are 91% and 95.5% respectively for 241Am-Be and 252Cf neutron sources when thickness of the borated polyethylene plate is 12.8 cm; The neutron shielding effects are 97.9% and 98.2% respectively for 241Am-Be and 252Cf neutron sources when thickness of the borated polyethylene plate is 22.4 cm. Conclusion The borated polyethylene plate is a kind of high effective shielding material against neutrons. It can be effectively used for neutron radiation shielding protection in neutron or neutron and mixed radiation fields.
  • DUAN Yu-ting, ZHANG Meng-long, CHAI Shou-dong
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    Objective To study the value of diagnosis with the multi-slice spiral CT in severe tetralogy of fallot of infant. Methods From January 2010 to March 2013,45cases (sever Tetralogy of Fallot of infant) were examined with 256-slice spiral CT preoperativly. All cases were then analyzed in work station with MPR(multiplanar recon-struction)、MIP (maximum intensity projection)、VR (volume rendering) and thin slice images,while compared with TTE (transthoracic echocar-diography) and surgical results. Results CT examination found that TTE misdignozed 4 cases of ductus arteriosus and 7cases of aortic coarctation. Meanwhile,CT shows 4 cases aorta pulmonary collateral arteries. In 45cases, surgical results confirmed 43 cases by 256-slice spiral CT, while 34 cases by TTE. The diagnosis accuracy of 256-slice spiral CT and TTE was respectively 95.6% (43/45) and 75.6% (34/45). There was statistically significant difference (P < 0.05) of the two inspections in diagnostic accuracy. Conclusion The inspection of 256-slice Spiral CT can benefit the preoperative diagnosis and operation program in severe infant with Tetralogy of Fallot.
  • LIU Xiao-ping, ZHOU Cheng
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    Objective To test and improve the accuracy of γ spectrometer, we participated a comparative analysis activity organized by IAEA. Methods Our analysis is based on two kinds of efficiency curve carried by two low background and high-purity germanium γ spectrometers respectively. Results The data is checked by a comprehensive set of standard of relative deviation, Z test, U test, accuracy and precision test and marked as acceptable. Conclusion The result demonstrates that the calibration sources of efficiency carve are reliable.
  • ZHAI Shi-jun, WAN Wei-xing, WU Na-jing, DU Xiao-qing, SU Gui-lin
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    Objective To explore the clinical effect of the radioactive nuclide strontium chloride(89SrCl2) and the association of 89SrCl2 and zoledronic acid in the treatment of transferable bone tumor. Methods 43 patients with transferable bone tumor were divided into two groups randomly, 21 patients were treated with 89SrCl2, 22 patients used the association of 89SrCl2 and zoledronic acid. The curative effect of remission of bone ache, the bone metabolism of metastatic focus, the change of the quality of life, and the reaction of hematological toxicity after the treatment was observed. The χ2 test was used in data analysis. Results In the single item treatment group, the pain relief rate was 71.4% (15/21), the effective rate of bone metabolism of metastatic focus was 33.3% (7/21) and the effective rate of improving whole body Karnofsky Performance Status (KPS) score was 57.1% (12/21) after treatment. In the combined treatment group, the palliative rate was 95.5% (21/22), the effective rate of bone metabolism of metastatic focus was 54.5% (12/22) and the effective rate of improving KPS score was 86.4% (19/22). There are statistically significant differences between the combined treatment group and the single treatment group in the pain relief rate and in terms of improvement in whole body KPS score (P < 0.05), and the hematological toxicities were 19.0% and 22.7% respectively (P > 0.05). Conclusion The 89SrCl2 and zoledronic acid has an obvious curative effect in the treatment of transferable bone tumor, and then it is thought as safety and reliability. Combined treatment with 89SrCl2 and zoledronic acid is more effective than single treatment with 89SrCl2.
  • WANG Yan, DU Li-qing, Fan Ti-qiang, XV Chang, CAO Jia, LIU Qiang
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    Objective Nude mice model of nonsmall-cell lung cancer(NSCLC) H460 cell was established to investigate the combined effects of radiotherapy and celecoxib. Methods Athymic mice bearing H460 were randomly divided into 3 groups:control, radiotherapy and radiotherapy plus celecoxib group. 4 weeks after treatment,mice were killed to detect tumor weight. The expressions of ataxia-telangiectasia mutated(ATM) and epidermal growth factor receptor(EGFR) in tumor tissues were detected by immune-histochmical (S-P) method. Results The tumor weight of radiotherapy plus celecoxib group was significantly different with that of radiotherapy group (P < 0.05). The expressions of ATM and EGFR were significantly lower than that in radiotherapy group. Conclusion Celecoxib promotes radiotherapeutic sensitivity of H460 by down-regulating the expression of ATM and EGFR. Celecoxib may presents potency in curing human lung cancer.