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  • 28 December 2010 Volume 19 Issue 4
      
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  • Design and Development of the Network Based System for the Supervision of Radioactive Sources
    YANG Yao-yun, SU Geng-hua, ZHANG Hui, et al
    2010, 19(4): 385-386. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.074
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    Objective To help the environmental protection authorities to upgrade the management of the related organizations and radioactive sources and improve the information level of nuclear technology utilization's supervision.Methods On the basis of investigation of requirements, the network based system for the supervision of radioactive sources was divided into application system and supervision system, based on MYSQL and SQL Server2005 respectively.Results The system satisfied the current requirements of the nuclear technology utilization's supervision and is in nationwide operation.Conclusion The system achieved the dynamic tracking management of radioactive sources and improved the efficiency and level of radiation safety supervision in nuclear technology utilizations.
  • The Observation about the Change of the Body Weight for Tumor Patients And the Bearing Tumor mice in Radiotherapy
    WU Di-jun, JU Yong-jian, NING Li-yan, et al
    2010, 19(4): 387-388. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.061
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    Objective To observe the change of the body weight for tumor patients and the bearing tumor mice in radiotherapy.Methods For 63 tumor patients, the body weight (BW) were measured before and afetr radiotherapy respectively, and then the change of BW were compared and analyzed with that of 23 healthy volunteers at the median treatment period.Also 45 mice bearing human galactophore tomor cells SK-BR-3 were divided into irradiation and non-irradiation groups, and the change of BW for these two groups were measured and analyzed.Results The average BW decreases in the irradiation groups' mice but increase in the non-irradiation groups' mice, and the change of BW in these two groups has the statistical significance respectively, also the difference between these two goups has the statistical significance.For the four groups' tumor patients including 63 tumor patients as a whole, the nasopharynx cancer, esophagus cancer and lung cancer, the average BW decreases, but only in nasopharynx cancer and lung cancer groups the statistical significance are found.And at the same period, the BW of healthy volunteers are maintained.Compared change of BW in the four tumor groups with that in the healthy volunteers respectively, except the esophagus cancer group, the statistical significance are found in the other three groups.Conclusion For tumor patients, perhaps the BW will lose in the period of radiotherapy, so the effect of lose of BW must be cared about.
  • Timely Variations of 222Rn Concentrations in a Typical Office
    YANG Wei-geng, HU Dan, ZHENG Guo-dong, et al
    2010, 19(4): 389-391. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.010
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    Objective To understand the variation behaviors of 222Rn concentrations with time in typical offices, and to provide an effective measure for carrying out the investigation or evaluation of 222Rn concentrations in offices.Methods The concentrations of 222Rn in a selected office were continuously monitored with the AlphaGUARD® for 9 months.The timely variations of 222Rn concentrations were statistically analyzed based on the measured data.Results Throughout the measurement period, the ratios of the maxima to the minima of daily averages, weekly averages, monthly and seasonal averages of 222Rn concentrations were 6.27, 2.63, 1.41 and 1.09, respectively.The ratio of averaged 222Rn concentration in weekends to that in weekdays was 1.17.During workdays, the averaged 222Rn concentration in working hours was 0.88 of that after working.Conclusion Although 222Rn concentrations in offices also change over time, the annual average of 222Rn concentration in an office can be approximately obtained with a 3 months of continuous measurement.
  • Research of Kill the Liver-cancer Cells by Transfect hNIS Gene into It Acrosse Radioactive Iodine Uptake
    ZHU Wei, NING Shang-yi, LI Su-ping, et al
    2010, 19(4): 391-393. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.062
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    Objective We transfected the human sodium/iodide symporter (hNIS) gene into liver-cancer cells to help it have the ability of iodine uptake to assess the effect of radioactive iodine uptake by liver-cancer cells and the role of anti-hepatoma by radioactive iodine.Methods Recombinant pCDNA-hNIS was transfected into HepG2 cells.The level of 131Ⅰuptake was assessed using transgenic liver cells stably expressing hNIS and effect of anti-hepatoma was determined by MTT method.Results 10-fold 131Ⅰuptake was observed in HepG2 cells transfected with pCDNA-hNIS compared with the control group by γ counting, correspondingly.The effect of anti-hepatoma was significantly higher in transgenic HepG2 cells compared with the controls.Conclusion HepG2 cells transfected with pCDNA-hNIS could uptake 131Ⅰ, accordingly, inhibited by 131Ⅰ.
  • Investigation of Radioprotective Effects of Aqueous Extract of S. obval-lata DC. Edgew on Sperm of Mice
    GUO Na, LI Wen-hui, ZHANG Guo-liang, et al
    2010, 19(4): 394-396. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.051
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    Objective To preliminarily explore the radioprotective effects of the aqueous extract of S.obval-lata DC.Edgew on the sperm of mice from radiation injury.Methods Before irradiated with 4 Gy of X-ray, administered the mice were different doses of aqueous extract of S.obval-lata DC.Edgew for 14 days.Drugs were respectively given directly to stomach at different dose for low, middle and high dose groups.35 days after irradiation, mice were sacrificed and measured the sperm deformity rate.Results Each treatment group with irradiation group compared with the irradiated group, Sperm deformity rate of the low dose, middle dose and high dose mice was lower than that of the model group, among which in the dose group and high dose group it was significantly lower than that of the exposure group, there was significant difference, P<0.05.Conclusion The natural herb S.obval-lata DC.Edgew active ingredient have some degree of radioprotective effects on the germ cells in mice.
  • Study on Discriminating 212Po α particle by Using Ordinary Aluminum Foil Absorber
    XU Jia-ang, LI Quan-tai, CHEN Ying-min, et al
    2010, 19(4): 396-398. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.074
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    Objective An absorber material of discriminating 212Po 8.78MeV α particle was developed by using ordinary aluminum foil instead of special absorber.Methods Deposition rate detectors with different mass thickness aluminum foil were exposed in the self-made 222Rn Chamber and 220Rn Chamber with the same exposure time.The suitable mass thickness aluminum foil for discriminating 212Po 8.78MeV α particle was selected after CR-39 were etched, and was tested for discriminating 212Po 8.78MeV α particle, which compared with the absorbing composite materials made by the United States.Results Through analysis on these experimental data, the absorbing law of discriminating different energy α particle by using ordinary aluminum foil was obtained.The discriminating performance of the self-made combined aluminum foil absorber for decay products of 222Rn/220Rn is superior to that of the American-made absorbers using in Japan.Conclusion The self-made CAFA can be used for discriminating 8.78MeV α particle determination.
  • Anti-tumor Effect of RNA Interference Silencing Survivin Gene Combined with X-ray Irradiation on Human Hepatoma Xenograft in Nude Mice
    SUN Ting, YANG Wei, CAO Jian-ping, et al
    2010, 19(4): 398-400. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.063
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    Objective To investigate the anti-tumor effect of RNA interference silencing Survivin gene combined with X-ray irradiation on human hepatoma xenograft in nude mice.Methods siRNA expression plasmids targeting Survivin genes packed by liposome were injected into human hepatoma xenograft which were irradiated with 5 Gy X-ray later.Tumor volumes at different time points and mean survival period of mice were observed.Expression level of Survivin, PCNA and intratumoral microvessel density were detected by Immunohistochemical staining.Apoptotic cells in tumor tissue were detected by TUNEL method.Results Tumor volumes of pGenesil-survivin+5 Gy group were significantly lower than those of the control, pGenesil-survivin and 5 Gy groups 3~21 days after the beginning of therapy.Mean survival period of mice in pGenesil-survivin+5 Gy group was the longest.Expression level of PCNA and intratumoral microvessel density in pGenesil-survivin+5 Gy group were significantly lower than those of pGenesil-survivin group and radiotherapy group 1 day after therapy.Percentage of apoptotic cells in tumor tissue in pGenesil-survivin+5 Gy group was significantly higher than other groups.Conclusion RNA interference silencing Survivin gene combined with radiotherapy could effectively inhibit cell proliferation and tumor angiogenesis, enhance apoptosis in tumor xenograft and its anti-tumor effect was more powerful than that of radiotherapy or RNA interference silencing Survivin gene.
  • Multicenter Study of Radiotherapy Combined with Sarcandra Glabra for Nasopharyngeal Carcinoma
    WEI Bo, WANG Ren-sheng, FENG Qi-ming, et al
    2010, 19(4): 401-402,404. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.065
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    Objective To observe the clinical effect of Sarcandra Glabra.Methods 100 patients with non-metastatic nasopharyngeal carcinoma in stage Ⅲ~IVa and untreated before accepted the treatment plan of Sarcandra Glabra combined with chemoradiation in June 2006 to August 2008.Oral intake Sarcandra 3 days before the radiation therapy, once 10g, three times a day, until the end of treatment.Radiotherapy with conventional radiotherapy protocol, chemotherapy with PF program, 100 cases were chosen who were staging Ⅲ~IVa and received intensity modulated radiotherapy combined with concomitant chemotherapy for the program PF as the control study.Results ① Two groups of primary and cervical lymph node metastases, efficience rate are 100%, the test group primary and cervical lymph nodes CR is 69%, 73%, and the control group is 80%, 81%.There is no significant difference between them.②Two groups of acute radiation reactions, leukopenia, and xerostomia are of no difference.The incidence and severity of oral mucositis and skin reaction in control group were lower than test group.③In test group, the 1 year and 2 years, overall survival, disease-free survival, recurrence rate and distant metastasis rates were:97%, 86%, 92%, 70%, 3%, 11%, 6%, 19%;control group was 100%, 93%, 97%, 81%, 1%, 5%, 2%, 12%.The difference was not statistically significant.④There is no statistically difference between two groups of xerostomia and the rate of radioactive tooth decay.There is statistically difference between two groups of difficulty in opening mouth and skin fibrosis, the control group is lower than the test group.Conclusion Intensity-modulated radiation therapy in normal organ tissue protection still has an absolute advantage.But combined chemoradiation plus sarcandra has a significant remission effect on the xerostomia and radioactive tooth decay caused by the deficiency of saliva secretion and it can improve the quality of patients' lives.It can protect parotid glands as well as intensity-modulated radiation therapy.
  • Comparative Study on Hematopoietic Damage of Mice Caused by High-dose of Gamma-ray Irradiation
    WU Hong-ying, WANG Yue-Ying, Li De-Guan, et al
    2010, 19(4): 403-404. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.071
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    Objective To study the effect of high-dose of gamma-ray irradiation on hematopoiesis injury and recovery of IRM-2 and C57BL/6J mouse.Methods The experiment was designed to study the effects of radiation (4Gy) on spleen index、CFU-S and DNA damage on the 9th day of IRM-2 and ICR mice and the effects of radiation (6Gy) on WBC change and its absolute value on the 45th days of IRM-2 and C57BL/6J mice.Results The IRM-2 mouse spleen index、CFU-S and DNA were higher than ICR mouse on the 9th days, and there were significant difference in CFU-S and DNA (P<0.01).The IRM-2 mouse WBC、RMC、HGB and HCT were higher than C57BL/6J mouse on the 45th days, and there were significant difference (P<0.01).Conclusion IRM-2 mouse hematopoiesis resumes quicker than C57BL/6J and ICR do after high-dose of gamma-ray irradiation.
  • Electromagnetic Radiation within Human Body and the Basic Theories of Traditional Chinese Medicine
    2010, 19(4): 431-435. https://doi.org/10.13491/j.cnki.issn.1004-714x.2010.04.049
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    Electromagnetic radiation is an intrinsic property of life phenomenon of the human body, and may symbolize the human Qi purported by Traditional Chinese Medicine.Based on this standpoint, elucidation is given to the scientific connotations of the basic theories of Traditional Chinese Medicine.The Theory of Channels and Collaterals:The electromagnetic radiation field within human body is characterized by non-local interference, resulting in interfering phenomena throughout the human body.The interfering beams form a whole network of solidarity, distributing strips (beams) of varied intensity on the surface of body.The beams carry corresponding biological information, and link the tissues and organs within the body.The Theory of Viscera:While mutual interference characterizes the electromagnetic fields induced by the electromagnetic radiation within human body, the quanta of the fields have the function of information transference, working as an informant for communicating information between tissues, organs, cells, biological molecules, etc, and playing an important role in transferring information for life movements.Therefore the quanta of human body are the Qi Informant for the regulation and adjustment of the viscera network in Traditional Chinese Medicine.The Theory of Heaven-human Correspondence:The earth biology exist in the spatio-temporal electromagnetic fields, which can be considered as the so-called Qi of the heaven and earth.The correspondence between the heaven and human beings is the mutual resonance between human body and spatio-temporal electromagnetic radiations.The theory of Zheng Differentiation Based Therapeutics:The Zheng in traditional Chinese medicine is a status of the quantum fields resulted from the electromagnetic radiation of the human body.Therapeutics based on the differentiation of Zheng is a therapeutic principle purposing health recovery through adjusting the status of the electromagnetic radiation fields within the human body.Constructing the Notion of Quantum TCM:Guided by the TCM holistism and dialectics, theoretically based on modern sciences including quantum theories, with the standpoint that the electromagnetic fields within human body are the Qi, utilizing the quantum forms of electromagnetic radiation, photon (quantum) radiation, energy (caloric), etc to study and explain the sciences within the traditional Chinese medicine frameworks that are concerned with human health and the development of diseases and their prevention, diagnose, therapy, rehabilitation, and healthcare.