LIU Pei-pei, CAO Yong-zhen
Objective To compare the dosimetric difference between volumetric modulated arc therapy (VMAT) and seven fixed field intensity modulated radiotherapy (7IMRT) in middle and advanced cervical carcimona. Methods Ten patients of middle and advanced cervical carcinoma who are unsuitable for brachytherapy for technical or medical reasons were enrolled in this study. Seven field IMRT and VMAT plans were generated for these patients. Dose volume histograms were adopted for the statistics of D2,D98,Dmean,conformal index(CI),homogeneity index(HI) of GTV and PTV,dose volumetric parameters of normal tissues,the small intestine,rectum,bladder and femoral heads,total accelerator output monitor units and total treatment time. Results The mean dose of the GTV for the VMAT plan is higher than that of the 7IMRT plan, which has statistical significant differences. The D2,D98,CI,HI of the GTV for both plans have no significant differences, and still the D2,D98,Dmean, CI,HI of the PTV for the two plans have no significant differences. VMAT has a better sparing effect on the V40,V46, Dmean of the rectum and the two plans have no significant differences on the V10,V20,V30, of the rectum. And the effect of other sparing on the small intestine,bladder and femoral heads is weak between VMAT and IMRT. The mean monitor units by VMAT is fewer by 35.68% in comparison with those of 7IMRT,the treatment time by VMAT is shorer by 61.5% in comparison with that of 7IMRT. Conclusion VMAT achieves equal or better target coverage and organs at risk sparing while using fewer monitor units and less time. Key words Cervical Carcinoma; Volumetric Modulated Arc Therapy; Fixed Field Intensity Modulated Radiotherapy; Dosimetrics