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  • 28 March 2008 Volume 17 Issue 1
      
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  • Effects of Long-term,Low Dose Rate Fission Neutron Irradiation on the Peripheral Hematological Cells in Rats
    JIANG Ding-wen, LEI Cheng-xiang, SHEN Xian-rong, et al
    2008, 17(1): 1-3. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.063
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    Objective To evaluate the effects of long-term, low dose rate fission neutron irradiation on the peripheral hematological cells in rats.Methods 96 rats were randomly divided into the control group and the irradiation group with low dose rate fission neutron (252Cf, 0.35mGy/h)irradiation 20.5h every day.8 rats of each group were killed at 14d, 28d, 42d, 56d, 70d after irradiation and 35d after the irradiation, and their peripheral hematological cells were tested respectively.Results Compared with the control group, peripheral blood WBC was reduced significantly at the dose of 0.3Gy and 0.4Gy (P<0.05), and was reduced remarkably at dose of 0.5Gy (P<0.01)and 35d after stopping irradiation (P<0.01).At dose of 0.2Gy, Peripheral blood RBC was abnormally higher comparing with the control group (P<0.01), accompanying with higher HCT and HGB, which suggests condensed blood.At the other point, RBC tend to become lower, but only at dose 0.5Gy, and the difference is significant comparing with control group (P<0.05).At dose of 0.3Gy, 0.4Gy and 0.5Gy, HCT were significantly lower comparing with control group.Comparing with control group, MCV was higher at 35d after stopping irradiation, and PLT was significantly lower in dose of 0.2Gy.Conclusion Long-term irradiation with low dose rate fission neutron could significantly reduce peripheral blood WBC, with less effects on RBC and PLT.The reduced WBC could not recover at 35d after stopping irradiation.
  • Adaptive Response of EL-4 Lymphoma Cell Cycle Progression Induced by Low Dose Radiation in Vitro
    LIU Shu-chun, WANG Zhi-cheng, LIU Yang, et al
    2008, 17(1): 3-4. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.061
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    Objective To explore the adaptive response of EL-4 cycle progression induced by low dose radiation in vitro.Methods EL-4 lymphoma cells were irradiated with the inductive doses (D1:25-200 mGy, 12.5 mGy/min)and the challenging dose (D2:0.5-3.0 Gy, 287 mGy/min).The interval time between D1 and D2 was 6 h.The cell percentages of each cell cycle phase were measured with flow cytometry.Results The cell percentages of G0/G1 phase in the D1 + D2 group with25-100 mGy (D1)and 1.5 Gy (D2)or 75 mGy (D1)and 25-200 mGy (D2)were invaribly lower than those in the D2 group, while the cell percentages of S phase increased significantly (P<0.05, P<0.01 or P<0.001).Conclusion The results suggest that EL-4 lymphoma cells were irradiated with 25-100 mGy at 6h before 1.0-2.0 Gy exposure.The low-dose radiation could induce the adaptive response of the cell cycle progression in vitro.
  • A Follow-up Survey of the Lymphocyte Micronucleus for Three Victims Seventheen Years After Shanghai “6.25” 60Co Radiation Accident
    DU Jie, CHEN Ying, YAN Xue-kun, et al
    2008, 17(1): 5-6. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.067
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    Objective To study the long-term effect on lymphocyte micronucleus and its clinical significance for the three victims seventheen years after Shanghai "6.25"60Co radiation accident.Method The MN and MNC frequency were observed by CBMN method.Results The MN and MNC frequency were still higher than normal even 17 years after the exposure.The MN frequency is related with the former radiation dose.The MNC consisting of ≥ 2MN is the hightest for "Long", but for"Jun"it consisted of 1 MN.The MN frequency is lower 17 years after the exposure than that of 5 years, but higher than 10 years.Conclusions The MN is one of important signs for long-term radiation effect.Special attention should be payed to the high level of MN remaining in the body for so long time.
  • Study on the Immunity State of Mouse Exposed to Mobile Phone Radiation During Embryonic Phase
    PEI Yin-hui, GAO Hui
    2008, 17(1): 7-8. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.045
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    Objective To study the effect of mobile phone radiation on mouse which exposed to radiation during embryonic phase.Methods Pregnant mice were exposed to mobile phone radiation.The mice's netrophile phage percentage and spleen lymphocyte transformation rate were detected respectively 2 months after birth.Results The netrophile phage percentage of experimental mice was seemly the same as that of control group, and there was no significant difference (P>0.05), but the spleen transformation rate showed the diverse trend.Conclusion The specific cellular immunity of mice, which exposed to mobile phone radiation during embryonic phase, was seen to be in a state of decreasement.
  • Radiation Exposure to Patients in Interventional Radiology
    CHEN Sheng-li, ZHU Dong-niang, ZOU Rong-zhu, et al
    2008, 17(1): 8-9,12. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.009
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    Objective To Analyze radiation exposure to patients in interventional radiology procedures and probe into the methods of reducing radiation.Methods Dose measurement system (Diamentor K1)equipped with DSA machine (Angiostar-Plus, Seimens, Gemany), analyzed dose-aera-production (cGycm2)and entering dose (mGy)of 432 patient having received interventional vascular radiology for diagnosis and treatment regressively.Results Dose value was (11 900±10 652)cGycm2 and (679±589)mGy for overall, DAP and DE mean value in photography was 3.34、1.56 times of fluoroscopy respectively.Conclusion Longer time fluoroscopy and abundant photograph were primary controllable factors of high radiation dose using DSA for interventional radiology, there were more contribution of photograph than that of fluoroscopy in radiation dose.Reducing the fluoroscopy pulse frequency and decreasing the photo number can debase patients radiation exposure effectively.
  • Changes of Calcitonin Gene-related Peptide and Endothelin-1 and Their Effects in Rats with Acute Renal Failure
    ZHANG An-yuan, ZHU Wei, SUN Qing, et al
    2008, 17(1): 10-12. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.049
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    Objective To study the effects of CGRP and ET-1 and to evaluate their changes during ARF.Methods The levels of CGRP and ET-1 in serum were measured by radioimmunity and was evaluated the renal function.Results The level of CGRP decreased significantly (P<0.05), and the level of ET-1 increased significantly (P<0.01)in serum.Conclusion The levels of CGRP and ET-1 in serum could reflect the renal functional state and clinical course in ARF.CGRP had a protected effect on the ischemic kidney.
  • Radiation Dose Reduction At a Price: The Effectiveness of a Thyroid Shield During Head CT Scanning
    FU Qiang, LU Tao, ZHANG Lin
    2008, 17(1): 13-13,19. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.010
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    Objective To assess radiation dose to the thyroid in patients undergoing head CT scanning and to evaluate dose reduction to the thyroid by load shielding.Methods A post-morterm was scanned by different model and study was undertaken to evaluate the dose reduction by thyroid lead shields and assess their practicality in a clinical setting. (a)No thyroid shields and (b)thyroid shield.One thermoluminescent dosimeters (TLDs)were placed over the thyroid gland center, A thyroid lead shield (Pb eq 0.5mm)was placed around the neck of post-morterm.Scan parameter、CTDIw and DLP were recorded.Results (a)0.207mSv; (b)0.085mSv.A mean effective radiation dose reduction of 58% was seen in the shielded versus the unshielded.Conclusion Thyroid exposure to scattered radiation from head CT scanning only once is associated with a low but not negligible risk of cancer, but accumulatived doses to the thyroid are serious, highlighting the need for increased awareness of patient radiation protection.Thyroid lead shielding yields significant radiation protection, which should be used routinely during head CT scan.
  • The Study on Measuring Accidental Dose Using OSL
    JIA Yu-xin, TANG-Qiang, MAI Wei-ji, et al
    2008, 17(1): 14-15. https://doi.org/10.13491/j.cnki.issn.1004-714x.2008.01.005
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    Objective Objective In order to find some dosimeters for irradiation accidents, the optically stimulated luminescence (OSL)characteristics of Integrate circuit (IC)chips were studied.Methods IC chips powder samples were prepared, and the OSL curves and their dose response and stability were measured.Results The OSL signals were observed while the samples were exposed to blue light or infrared light, and the signal is linear to the absorbed dose.Conclusion It is possible that the IC chips can be used as dosimeters for irradiation accident.