XU Jin-yan, LI Wen-hui, LIU Jian-bo, et al
Objective To preliminarily explore the radioprotective effects of the aqueous extract of S.obval-lata DC.Edgew on mice from radiation injury.Methods mice from radiation injury, as target of the research, are been intragastricly administrating and receive different doses of aqueous extract of S.obval-lata DC.Edgew in IR+medication groups, and corresponding amount of normal and saline for IR group.After 5 days, mice are been receive a total body irradiation at a does of 6Gy X-ray.Then repeated intragastric administrating was given for 5 days and observed.On the 18th day, the body weights to measure, RBC、WBC、PLT、Hb of venous blood, the bone DNA contents (A value) and marrow nucleated cell population, the spleen weights.Results In IR+medication groups, IR group compared with the body weights, WBC、PLT, the bone marrow DNA contents (A value) and nucleated cell population of mice rise obviously, there were significant statistical differences among them, P<0.01 (PLT of IR+LD group、the spleen weights、the spleen index, P<0.05), The differences are more obvious in the IR+HD group.However, There are no statistics difference to the contents of RBC、Hb of peripheral blood in all irradiation groups, P>0.05.Conclusions The active components of the aqueous extract of S.obval-lata DC.Edgew express out the obvious radioprotective effects for hemopoietic system of mice and can stimulate proliferation of the spleen cell, improve immune function of mice.No obvious difference to the contents of RBC、Hb of peripheral blood in all irradiation groups is possiblly related with the long metabolism cycle of RBC、Hb and the delay of hematopoietic tissue delivery RBC and Hb synthesis.
