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  • 28 June 2006 Volume 15 Issue 2
      
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  • Nuclear Track Method to Measure Neutron Flux
    ZHANG Zhi-jun, LEI Jia-rong, YUAN Yong-gang, et al
    2006, 15(2): 129-130,132. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.001
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    Objective To discuss how to use nuclear tracks method to measure neutron flux.Methods Dividing neutron to thermal neutron、middle neutron and fission neutron with solide state nuclear tracker detector that make up of three detecting units to detect neutron flux of diffirent energy.Results The relatively error of 9.50 cm and 19 cm's detecting result of Am-Be neutron Source are 2.64% and 5.85%.Conclusion Solide state nuclear tracker detector can be used to measure neutron flux, and it has little volumeand unobvious disturbance to neutron field.
  • The Effect of Electromagnetic Irradiation on PKC Translocation and Activation
    DENG Zhao-hui, WANG Deng-gao, ZHANG Lei, et al
    2006, 15(2): 131-132. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.002
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    Objective To study the effect of electromagnetic irradiation on PKC translocation and activation.Methods After exposure to 5 W/cm2 microwave, the change of PKC kinase activity in rat hippocampus was detected by Takai method, AMPA receptor phosphorylation level was determined by Western-blotmethod.Results 5 W/cm2 microwave irradiation increased PKC kinase activity after exposure 3~5d and this effect continued for 15d, and the irradiation have no obvious effect on AMPA receptor phosphrylation in rat hippocampus.Conclusion The results showed that PKC-AMPA pathway may not be involved in the central nervous system injury induced by 5 W/cm2 microwave irradiation.
  • The Activation of Death Receptor Signaling Pathways on Cell Membrane by Ionizing Radiation Activaties
    YANG Long, XU Xiang-yu, ZHAO Guo-liang, et al
    2006, 15(2): 133-134,137. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.003
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    Objective To study the effects of activation of death receptor signaling pathways on cell membrane in the process of apoptosis induced by ionizing radiation.Methods The BET-2 cells were radiated with 0、1、3、5、7、10Gy and divided into control group and caspase-8-specific inhibitor IETD-fmk-treated group.Apoptosis were measured by Annexin-V staining, caspase-8 and caspase-3 were determined at different time phases after irradiation.Results Apoptosis was induced and caspase-8 and caspase-3 were increased in a pattern of dose-effect and time-course after irradiation and decreased after treated with IETD-fmk partly.Conclusions Apoptosis was induced by activation of the death receptor signaling pathways on cell membrane after ionizing radiation directly.
  • Study on the Action Guidelines for Medical Support Team for Nuclear and Radiological Emergency
    LIU Chang-an, LIU Ying, GENG Xiu-sheng
    2006, 15(2): 135-137. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.004
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    Objective To study the action guidelines for medical support team for nuclear and radiological emergency.Methods It is based on the experience and lessons learned in the course of meeting the emergencies preparedness and response of nuclear and radiological emergencies in China and abroad with the reference of the relevant reports of International Atomic Energy Agency.Results Essential requirements and practical recommendations for the roles, responsibilities, emergency preparedness, principles and procedures of medical assistance at the scene, as well as the radiological protection of medical support team were provided.Conclusion The document mentioned above can be applied to direct the establishment, effective medical preparedness and response of the medical support team for nuclear and radiological emergency.
  • Effects of Neutron Radiation On Expression of Extracellular Matrix in Renal Tissue
    PENG Wu-lin, CHEN Tie-he, JIANG Dingwen, et al
    2006, 15(2): 138-139. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.005
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    Objective To determine the effect of neutron radiation on expression of extracellular matrix (ECM) in renal tissue.Methods Renal cells separated from rats were exposed at 0.26-1.21 Gy neutron, and were maintained in serum-free medium for a further 48 h.Primary cultures were tested with RIA methods for expression of hyaluronan (HA), laminin (LN) and precollagen-Ⅲ(PCⅢ).Results HA and PCⅢ were reduced remarkably by 0.62 Gy neutron, and were not effected by 0.29 Gy and 1.21 Gy neutron;Irradiated with dose of 0.29 Gy and 1.21 Gy neutron could lead to a remarkable elevation of LN, but 0.62 Gy neutron has no effects to LN.Conclusion Lower dosage of neutron could lead to an altered production of ECM in rat renal tissue.
  • Study on Biological Effect on Mice and Use Safety of 830nm Semiconductor Laser
    LI Ke-qiu, LI Jian, MIAO Xu-hong, LIU Shu-juan, LI Guang
    2006, 15(2): 140-141. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.006
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    Objective To study biological effect on mice by 830nm semiconductor laser in different dosage, and determine the optimal irradiating dosage by observing and analyzing the immunoregulation and cytogenetical damage of mice after irradiation.Methods The spleen and thymus areas of Kunming mice were irradiated in vitro by 830 nm semiconductor laser of 30mW for 5 min, 10 min and 20 min per day respectively, then the blood samples were collected from orbital vein.Further, the spleen tissue and sternum marrow were collected soon after the mice were killed.Afterwards, IgG, dopamine, serotonin in serum were detected respectively.Besides these, the rate of lymphocyte transformation and the rate of micronuclei in marrow polychromatic erythrocytes were also determined.Results With the extending of irradiating time, the detected factors changed differently.Statistically, there were differences in IgG concentration and the rate of lymphocyte transformation between 10 min group, 20 min group and control group respectively, but no difference between each experimental group were found.Compare with control group, serotonin concentration in 10 min group increased, and there was statistical difference between these two groups, while there was no difference in dopamine concentration among each group.Besides these, the rate of micronuclei in 20 min group increased.Conclusion In this study, irradiation by semiconductor laser for appropriate time can improve immunofunction of mice, but irradiation in high dosage will result in the damage of genetic material.The optimal time of irradiation by 830 nm semiconductor laser was 10 min.
  • The Radioactivity Levels in the Main Lakes of Shandong Basin in East Line of South to North Water Diversion
    CAO Jing-li, XU Jia-ang, CHEN Ying-min, et al
    2006, 15(2): 142-143. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.007
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    Objective To study the radioactivity levels in the main lakes of Shandong basin in east line of South to North water diversion.Methods The Gross-alpha and gross-beta activities were determined by using alpha-/beta-discrimination liquid scintillation counting (alpha-/beta-LSC) by direct measurement of the dried resin after extraction;226Ra using NIST radon emanation standards;137Cs, 60Co, 238U, 232Th, 40K with gamma-ray spectrometry using a HPGe-γ detector;90Sr using general deposition by sulphate and EDTA.Results The average levels of gross-alpha、gross-beta are 9.69×10-2、2.82×10-1 Bq·L-1 respectively.The average levels of 90Sr、137Cs are 5.50×10-3, 7.60×10-4 Bq·L-1 respectively.There is no counts in detecting 60Co by using the HPGe-γ detector.The average levels of 238U, 226Ra, 232Th and 40K are 1.37×10-2、6.48×10-3、13.95×10-4 and 1.21×10-1 Bq·L-1 respectively.Conclusion The levels of gross-alpha and 238U in Chishan village are higher than the average levels in the main lakes of Shandong basin.The average radioactive levels of others in the main lakes of Shandong basin are about to the background levels.
  • The Effect of G-CSF on Malignant Transformation of Wistar Rat lung Cells Irradiated with 60Coγ Ray
    YANG Su-xia, LI Yu, FAN Fei-yue
    2006, 15(2): 144-146. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.008
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    Objective To study the effects of G-CSF on malignant transformation of Wistar rat lung cells irradiated with 60Coγ ray.Methods MTT method, soft agar colony formation test and flow cytometry were used to investigate alteration of the growth, colony formation efficiency and cell cycle among control cells, cells irradiated with 60Coγ ray singly, and cells treated with G-CSF continuously after irradiation of 60Coγ ray.Result Compared with cells irradiated with 60Coγ ray singly, G-CSF could inhibit cell growth (cells irradiated with 60Coγ ray after pretreatment with G-CSF), delay the soft agar colony formation and reduce the cells entering cell cy cle.Conclusion G-CSF can slow doun the process of malignant transformation induce by 60Coγ ray.
  • Clinical Applied Study on Metal Stent and Radiotherapy for Carcinomatous Stricture of Esophagus
    CAI Zhi-chun, QU Feng-sheng, ZHANG Xin-yi, et al
    2006, 15(2): 146-148. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.009
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    Objective To explore the method of domestic-made esophageal stent implantation undex X-ray, the possibility and value of radiotherapy with stent for carcinomatous stricture of esophagus.Methods The datas of 158 patients with esophageal stent implantation und X-ray were summarized.The possibility and effective of conventional divide irradiation with esophageal stent were analyzed emphaticly in 86 patients.Results 162 esophageal stents were implanted successfully in 158 patients except one failure for esophageal stenosis severely.Dysphugia was relieved immediately after the esophageal stent implantation.Binding with radiotherapy especially, the quality of life was improved obviously and the survival period was prolonged.Complication such as hemorrheues and perforation were not seen among all the patjents.Conclusion The method of domestic-made esophageal stent implantation under X-ray is safely, and the effe ctive.It would be more effective if with esophageal stent.Esophageal stent implantation and radiotherapy bave become the first choice of treatment for carcinomatous stricture of esophageal in its late slage.
  • The Evaluation of Radiation level and Dose of Workers in Guangzhou Metro Line 1
    ZHANG Lin, HU Can-yun, MENG Xiaolian, et al
    2006, 15(2): 149-150,152. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.010
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    Objective To find out the level of radiation and effective dose of workers in Guangzhou Metro line 1.Methods In metro stations, external Gamma-ray exposure rates were obtained by FD-71A radiance measurer, 222Rn and 220Rn concentrations were obtained by using Rn-Tn solid state nuclear track detectors developed by The National Institute for Radiological Protection and Nuclear Safety, Chinese Centre for Disease Control.The annual Effective dose from Gamma、222Rn and 220Rn were calculated.Results The external Gamma-ray exposure average rate is 17.74×10-8 Gy/h, The average concentration of 222Rn is 59.8 Bq/m3, The average concentration of 220Rn is 32.1 Bq/m3.The total annual effective dose from Gamma、222Rn and 220Rn is 2.878mSv/a.Conclusion In the stations of Guangzhou in metro line 1, no more effective radiation dose to the workers has measured.
  • A Comparison Research of the Energy Response for Seven Commercially Available Mammography Dosimeters
    WANG Jian-chao, YUE Bao-rong, WEI Ke-dao
    2006, 15(2): 151-153. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.011
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    Objective To evaluate the least energy dependent response dosimeters in the comparison research.Methods According to GB/T 19629-2005, the energy response of seven commercially available mammography dosimeters was determined for ten standard radiation qualities in the range 25~40kV at the SSDL using a refreme-class dosimeter.Results The error range of correction factors of energy response, three type chambers are 3.0%, 3.3% and 3.3% reprectively;three type semiconductor detectors are 3.8%, 36% and 43% and one type thermoluminescent dosimeter is 29%.Conclusion Radcal 9095 dosimeter have the least energy response.Other type chambers have better energy response than semiconductors and TLD dosimeters.
  • Investigation on Accordance of DNA Double-strand Break of Blood Between in Vivo and in Vitro Irradiation Using Single Cell Gel Electrophoresis
    LIU Qiang, JIANG En-hai, LI Jin, et al
    2006, 15(2): 153-155. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.012
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    Objective To observe the consistency of DNA double-strand break between in vivo and in vitro irradiation, as a prophase study in radiation biodosimetry using single cell gel electrophoresis (SCGE).Methods Detect DNA double-strand break after whole-body and in vitro radiation in mice lymphocytes using neutral single cell gel electrophoresis.The comet images were processed by CASP software and all the data were analysed by SPSS12.0.Results There is no difference between in vivo and in vitro irradiation group in HDNA%、TDNA%、CL、TL、TM and OTM.Conclusion The result of neutral single cell gel electrophoresis shortly after in vitro irradiation can precisely reflect the DNA double-strand break of lymphocytes in whole-body irradiation.
  • Establishment of Colloid Gold Immunity Chromatography Assay for Cardiac Troponin I (cTnI)
    WANG De-zhi, CHEN Ji-ying, Qin Li-li et al
    2006, 15(2): 156-157. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.013
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    Objective To establish the colloid gold Immunity chromatography assay for cardiac troponin I.Methods To purifiy cTnI from human cardiac muscle and immunize rabbit with it.cTnI antibody of rabbit anti-human cardiac muscle has been prepared and colloid gold immunity chromatography assay was established by using immunity chromatography technology.Results Antiserum titles of cTnI were 1:100000, Ka=2.38×109 L/mol;Methodological index:Sensitivity:5 ng/ml;Specificity:cTnI is no cross-reaction with cTnT, cTnC and CK-MB.Conclusion The assay is higly specific, quick and simple.It can be widely used for the early diagnosis of AMI and scientific research.
  • Research on Breast Damage of Women After Chest Multi-layer CT scanning
    ZHANG Tao, TANG Ri-jie, PENG Jun-qin, et al
    2006, 15(2): 158-160. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.014
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    Objective To discuss the breast damage caused by the x-ray scanning.Methods To calculate the chest and breast scanning layers of every case with GE 16 layer-CT machine on 38 female patients, choosing voltage 120 KV, electric current 150 mA、200 mA、250 mA and pitch 0.935 or 1.375.Then calculate the chest and breast scanning layers of every case, register the bar, where the scan program can be set, record the DLP and work out the DLP of the breast according to data noted above.Meanwhile, analyze the influence of mA、layer、pitch on DLP.Results In the 38 cases, plane scanning layers of chest range from 19 to 33, and breast from 7 to 19, with the latter accounting for 27.59%~66.66% of the former.So was the DLP.When scanning the same ranges, choose different mAs and pitch, which exerts a great influence on the DLP.Conclusion Choosing 150mA, 1.375 pitch, 7.5mm layer on female of moderate bodily form can guarantee the quality of the picture sufficiently and a relative lower DLP.At the same time, make a good use of its software to rebuild in a variety of ways.Also, a better quality picture can be received.Choosing the parameters such as pitch, numbers of scan layer, slice and mA scientifically can reduce the quantity of X-ray the breast received.
  • Experimental Study of the Dose Distribution of 125I Seeds Sources Brachytherapy Prostate Cancer
    WANG Dao-ping, YUAN Shuyu, DAI Guang-fu, et al
    2006, 15(2): 161-163. https://doi.org/10.13491/j.cnki.issn.1004-714x.2006.02.016
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    Objective To study the dose distribution of 125I seeds in interstitial brachytherapy prostate cancer.Methods Tumour phantom (Φ50×15mm) was used by employing.3-D the treatment planning system (3-D TPS) in the experiment simulation.Dose distribution of prostate cancer was determined in tumour phantom using thermoluminescence dosimetry method (TLD).Results The experimental results indicated that dose distribution was nonuniform.We find the dose distributions of prostate cancer was relatecl with geometric configuration and the number of 125I seeds.Conclusion The dose of 125I seed source over the surface is the highest which attenuated very rapidly with distance.The narrower the interstitial space of seeds, the higher the dose in the cancer.