SHEN Xiu, ZHANG He-qing, WU Meigao, et al
Objective This paper reports the research results of sub-lethal 137Cs γ-rays irradiation on Kunming species mice, and the damage degree of different irradiation dosages and stages in mice were determined.The aim is to provide background data for the basic research of physiological indexes about radiation damage, and thus offer reference data for functional health-food of anti-irradiation, as well.Methods The Kunming species mice were irradiated by 2, 3, 4, 5Gy of 137Cs γ-rays, and the samples of blood, hematopoietic system, immune system and genetic system were taken and determined, respectively, at 3, 5, 7, 14 and 21 day after irradiation.The varieties of biological indexes at different time were obtained, including the white blood cells (WBC), micro-kernel rate, DNA content of marrow, thymus index and spleen index, and so forth.Results The research manifested that all kinds of the biological indexes showed a relationship between dosage-time response and the irradiation intensity.The damage showed the most severe stage was at 3-5 days after irradiation, and then entered the recovery stage began.It did not get normal until after 21 days.By statistics treatment, some indexes of irradiated mice were of the evident differences compared with the control ones without irradiation.Conclusion Aftere sub-lethal dosages of γ-rays irradiation, the determined results of the various biological indexes in mice were reasonable and reliable.All indexes are available to the research of irradiation damage, and can be applied to the drug research of irradiation protection as well.