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  • 28 March 2003 Volume 12 Issue 1
      

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  • ZOU Jian-ming, SUN Quan-fu, YUAN Yong-ling
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    Objective To identify the major determinants of nasopharyngeal carcinoma (NPC) in the high-background radiation areas (HBRA) in Yangjiang, China.Methods A nested case-control study was conducted based on 106517 subjects.98 cases that died of NPC were detected during a follow-up program for 9 years.Univariate analysis and multivarate non-conditional logistic regression were used to analyze associations between the exposure factors and NPC.Results Multivariate conditional logistic regression analy sis revealed that education levels, salted fish intake, the history of chronic rhinitis and the family history of NPC were independent risk factors of NPC.Tobacco smoking and alcohol consumption were not significantly related to NPC risk.The ORs of NPC risk comparing HBRA and a nearby control area before and after adjustment for the major risk determinants identified in the present study was 0.86 and 0.87, respectively.Conclusion Salted fish intake was a strong risk factor of NPC.Education, the history of chronic rhinitis and the family history of NPC were also related to NPC risk.The exposure to high background radiation in HBRA of Yangjiang was not related to NPC risk with or without the adjustment for those major risk determinants of NPC.
  • SUN Zeng-jun, MA Yu-qin, LIU Jun-Qing, et al
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    Objective To observe the long-term curative effect and red blood cell immune function in patients with Graves' Disease (GD) after radioactive iodine (131I) treatment.Methods To observe the hyperthyroid symptoms、phy sical signs and to measure the concentration of FT3、FT4、FSH by radioimmunoassay、the percent of RBC-C3BR-YR (%)、RBC-IC-YR (%).Results Patients with GD treated by 131I after three months, these hyperthyroid symptoms、Physical signs are alleviatecl and even vanished in patients who were teated by 131I after 1.5 years, RBC-C3bR-YR (%) are normal in all patients;but RBC-IC-YR (%) are higher than before treatment with 131I, then become lower after three months, treatment by 131I but they were higher than those in normal group, when treated with 131I after 1.5 years, RBC-IC-YR (%) are normal, the relationship between RBC-C3bR-YR (%) and RBC-IC-YR (%) are positively interacted.Conclusion The 131I treatment produces a good rapid curative effect for GD patients, the disorder state of the red cell immune adherence system is repaidly corrected and this effect is unidirectional.So RBC-C3bR-YR (%)、RBC-IC-YR (%) are the useful predictors of GD remission and their relationship、RBC-IC-TR (%) are helpful in explaining the mechanism of radioactive iodine therapy and are the predictors of GD remission after 131I treatment.
  • LI Jin, WANG Qin, TANG Wei-sheng, et al
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    Objective Biological dose estimation was made by using chromsome aberration analyses for victims of the 60Co radiation source accident.The dynamic changes of cytogenetics for victims were observed.Methods Lymphocyte cultures, preparation slides and stains were performed as our laboratory protocol with modification.The radiation status was tested by using Poisson distribution.Results The biological doses were estimated to be 2.42 ("Tian") and 2.17 ("Wang") respectively on the 11th day.The doses were coincided with the physical dose and clinical diagnosis.The dicentrics and ring frequencies decreased with time.Conclusion Chromosome aberration analysis is an ideal method for estimating biological doses.
  • CHENG Qi-jun, ZHANG Zeng, XU Zheng-chang, et al
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    Objective The effects of pitch, collimation and table speed on radiation dose to patient were studied.Methods The TLDs and a standard CT head dosimetry phantom were used for radiation dose measurements.All data were acquired on the third-generation scanner (Somatom plus 4, Siemens).The study was carried out at 10, 8, 5 mm collimation for pitches of 0.5, 1, 1.5, 2.Table speed was 5, 8, 10, 12, 15, 16 mm/1.5s.Results The average radiation dose at central hole and that at peripheral were measured.Results As the tube voltage and the round speed is given the radiation dose increases with increase in tube current and collimation, decreases with the table speed and pitch.The radiation dose at central hole was nearly equal to that at peripheral hole.There was no significant difference between them with statistical test.Conclusion As the tube voltage, tube current, round speed is given the average dose at central hole and that at peripheral hole are inverse proportional to pitch.The collimation less affected on the radiation dose in this study.