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  • 28 April 2024 Volume 33 Issue 2
      
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  • Interpretation of Gamma-ray spectrometry method for the determination of radionuclides in environmental and biological samples
    TUO Fei, ZHOU Qiang, YANG Baolu, LI Zeshu, QIN Weihao, KONG Shuying
    2024, 33(2): 111-115,122. https://doi.org/10.13491/j.issn.1004-714X.2024.02.001
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    As a rapid analytical method for both the types and activities of γ radionuclides, the γ-ray spectrometry method is widely used in the measurement of γ radionuclides in environmental and biological samples. The Gamma-ray Spectrometry Method for the Determination of Radionuclides in Environmental and Biological Samples (GB/T 16145—2022）was implemented on July 1, 2023, replacing the Determination of Radionuclides in Soil by Gamma Spectrometry (GB/T 11743—2013), Determination of Radionuclides in Water by Gamma Spectrometry (GB/T 16140—2018), Gamma Spectrometry Method of Analyzing Radionuclides in Biological Samples (GB/T 16145—2020), and Determination of Radionuclides in Air by Gamma Spectrometry (WS/T 184—2017). The background of the revised standard, the content and basis of the main revisions, and some issues that need to be discussed are briefly explained in this paper, in order to provide a useful reference for the detection of radioactivity in soil, water, biological, and air samples, as well as samples of similar matrices.
  • Differential mRNA expression in fractional low-dose radiation-induced senescence of HBE cells
    ZHANG Lingyu, HUANG Weixu, CAI Yashi, LI Huixian, ZHANG Min, WEN Changyong, YANG Ping, ZOU Jianming, CHEN Huifeng
    2024, 33(2): 116-122. https://doi.org/10.13491/j.issn.1004-714X.2024.02.002
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    Objective To explore the differentially expressed mRNAs and related biological processes and pathways in fractional low-dose ionizing radiation (LDIR)-induced senescence of normal human bronchial epithelial (HBE) cells by high-throughput mRNA sequencing and bioinformatics techniques. Methods Senescence-associated β-galactosidase staining and senescence-associated secretion phenotype gene mRNA and protein expression levels were measured at 24 and 48 h after irradiating HBE cells 7 times at doses of 0, 50, 100, and 200 mGy, respectively. The differentially expressed genes were screened by high-throughput sequencing for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Results The senescence-positive area of fractional low-dose irradiated HBE cells increased in a dose-dependent manner (P < 0.05). The mRNA levels and protein expression of transforming growth factor-β1(TGF-β1) and matrix metalloproteinase-9(MMP-9) genes were increased in the 100 mGy × 7 and 200 mGy × 7 groups at 24 and 48 h after the end of irradiation compared with the control group. High-throughput sequencing showed that there were 882, 475, and 1205 differentially expressed mRNAs in each dose group compared with the control group. GO analysis showed that the differentially expressed mRNAs in each dose group were mainly enriched in biological processes such as cell cycle regulation, regulation of nitrogen compound metabolic process, regulation of cell division and response to stimulus. KEGG analysis showed that the differentially expressed mRNAs were mainly enriched in the pathways of cell cycle, cell senescence, and ferroptosis. Conclusion Fractional LDIR induced senescence in HBE cells, and differentially expressed mRNA-associated biological processes and pathways in senescent cells are related to cell cycle and cell senescence.
  • The impact of bladder and bowel preparation on the precise implementation of radiotherapy for prostate cancer
    MA Yaru, LIN Maosheng, CHEN Jiongjia, DING Zhenhua
    2024, 33(2): 123-128. https://doi.org/10.13491/j.issn.1004-714X.2024.02.003
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    Objective To observe the daily bladder and bowel preparation of patients with prostate cancer by cone-beam computed tomography (CBCT), and analyze its impact on the precise implementation of radiotherapy for prostate cancer and side effects. Methods We retrospectively analyzed 38 patients with prostate cancer who underwent volumetric modulated arc therapy. The number of radiation fractions for each patient ranged from 25 to 35. A CBCT scan was performed before each daily radiation therapy, and the number of scans for each patient ranged from 25 to 40. Setup errors were adjusted to ensure that the tumor was targeted and the rectum wall was not in the high-dose target area of the prostate. There were 93 instances where treatment could not be successfully implemented and re-preparation and re-scanning were required. We calculated the success rate of treatment and setup errors, compared radiotherapist-adjusted error values under different bladder and bowel preparation conditions, and recorded radiotherapy-related side effects. Results The success rate of treatment in the 38 patients was (92.14 ± 5.25)%. Among the 93 instances of seriously inadequate preparation, 48.4% were due to insufficient bladder filling, and 30.1% were due to intestinal bloating. Radiotherapy side effects were negatively correlated with the success rate of treatment (r = -0.393, P = 0.015). When bladder filling was sufficient, there were no significant differences in radiotherapist-adjusted error values in the left-right (LR), superior-inferior (SI), and anterior-posterior (AP) directions between adequate and inadequate bowel preparation (P > 0.05). When the bladder was moderately or insufficiently filled, there were significant differences in radiotherapist-adjusted error values in the LR, SI, and AP directions between adequate and inadequate bowel preparation (P < 0.05). Conclusion Insufficient bladder filling and intestinal bloating are the main factors influencing the successful implementation of radiotherapy for prostate cancer. When the bladder is sufficiently filled, bowel preparation does not affect prostate position change.
  • Analysis of micronucleus rate in 394 radiation workers with cytokinesis-block micronucleus method
    LIU Haixiang, ZHAO Hua, GAO Yu, ZHANG Jie, ZHANG Xueqing, XIA Ying
    2024, 33(2): 129-134. https://doi.org/10.13491/j.issn.1004-714X.2024.02.004
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    Objective To analyze the micronucleus rate of radiation workers and to provide accurate occupational health monitoring basis in radiation workers exposed to low-level ionizing radiation for a long time. Methods The radiation group consisted of 353 radiation workers who had been exposed to ionizing radiation during work, while the control group consisted of 41 radiation workers who had not yet been exposed to ionizing radiation before work. The cytokinesis-block micronucleus method was used to determine the micronucleus rate. Results The average micronucleus rate in the radiation group was significantly higher than that in the control group (t = -2.95, P < 0.05). In the radiation group, the micronucleus rate gradually increased with age, and the difference was statistically significant (F = 8.36, P < 0.05). The micronucleus rates of workers with > 10 and > 30 years of service were significantly higher than those of workers with < 10 years of service (χ2 = -44.79, -60.47, P < 0.05). The micronucleus rate in females was significantly higher than that in males (t = 3.93, P < 0.05). The micronucleus rates in the diagnostic radiology group and the industrial detection group were significantly higher than that in the control group (t = 3.51, 3.65, P < 0.05). Conclusion The micronucleus rate has increased among the radiation workers exposed to low-level ionizing radiation for a long time. It is necessary to further strengthen occupational health monitoring and radiation protection education for radiation workers, especially the medical workers that constitute the largest population of radiation exposure workers.
  • Effects of 5G mobile phone radiofrequency radiation exposure on male mouse fertility
    ZHANG Zhaowen, ZHOU Guiqiang, GUO Ling, QIN Tongzhou, WANG Xing, DING Guirong
    2024, 33(2): 135-141. https://doi.org/10.13491/j.issn.1004-714X.2024.02.005
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    Objective To clarify the effects of 5G mobile phone radiofrequency radiation exposure on male mouse fertility and to preliminarily explore the underlying mechanisms. Methods Healthy male C57BL/6 mice aged 7-8 weeks were randomly assigned to Sham group, 3.5 GHz radiofrequency radiation group, and 4.9 GHz radiofrequency radiation group, with 16 mice in each group. The mice were exposed to 3.5 GHz or 4.9 GHz mobile phone radiofrequency radiation for 42 consecutive days (1 h per day). The sperm quality was evaluated using sperm count, deformity rate, and motility. H&E staining was performed to assess testicular tissue structure by observing the morphology of spermatogenic cells at various development stages, the diameter of seminiferous tubules, and the thickness of seminiferous epithelium. The sperm mitochondrial function was assessed using sperm mitochondrial membrane potential and testicular ATP content. The fertility of mice was evaluated through fertility rate, litter size, and survival rate of offspring. The underlying mechanisms were explored by detecting the methylation of LRGUK gene and its mRNA and protein levels. Results Compared with the Sham group, there were no significant changes in sperm count in the 3.5 GHz and 4.9 GHz groups; however, the sperm abnormality rate significantly increased (P < 0.05) and sperm motility significantly decreased (P < 0.05). The structure of testicular tissue, the function of sperm mitochondria, and fertility of mice showed no significant changes as compared with the Sham group. The methylation level of LRGUK gene in the testes significantly increased, while the mRNA and protein expression levels significantly decreased. Conclusion Exposure to 3.5 GHz and 4.9 GHz mobile phone radiofrequency radiation for 42 consecutive days can lead to an increase in sperm deformity rate and a decrease in sperm motility in mice, but has no significant effect on fertility, which may be related to an increase in methylation level of the LRGUK gene in the testes.
  • Analysis of occupational health examination data of 215 radiation workers from hospitals in Jiayuguan, China
    WANG Caihuan, LIU Jun
    2024, 33(2): 142-147. https://doi.org/10.13491/j.issn.1004-714X.2024.02.006
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    Objective To understand the effects of long-term exposure to ionizing radiation on the health of radiation workers. Methods A total of 215 radiation workers were randomly selected and assigned to the exposure group and 197 non-radiation workers were assigned to the control group. The occupational health examination results of the two groups were compared and analyzed. Results The WBC count of the exposure group was lower than that of the control group (P＜0.05), while the abnormality rates of ocular lens, ECG, liver function, and thyroid function were significantly higher in the exposure group than in the control group (P＜0.05). In the exposure group, the abnormality rate of liver function was lower in females than in males, and the abnormality rate of hemoglobin level was higher in females than in males (P＜0.01). The abnormality rate of ocular lens increased with age (P＜0.01). The abnormality rate of hemoglobin level was different among different age groups (P＜0.01). The abnormality rate of ocular lens increased with increasing years of service. The abnormality rates of RBC count and hemoglobin level in the general radiotherapy group were higher than those in the interventional radiotherapy group (P＜0.01). Sex was the influencing factor for abnormal liver function (P＜0.01). Conclusion Prolonged exposure to low doses of ionizing radiation can adversely affect the health of radiation workers in medical institutions.
  • Analysis of factors influencing lymphocyte micronucleus in industrial radiation workers in Gansu Province, China
    LI Ye, WU Xiaoqin, LIU Gang, DI Hongjie
    2024, 33(2): 148-152. https://doi.org/10.13491/j.issn.1004-714X.2024.02.007
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    Objective To analyze micronucleus abnormalities in the peripheral blood lymphocytes of industrial radiation workers and the influencing factors, and to provide a reference for radiation protection. Methods The occupational health monitoring data of 661 industrial radiation workers were collected from the occupational health examination system of Gansu Provincial Center for Disease Control and Prevention. The abnormalities in the micronucleus of peripheral blood lymphocytes were analyzed. The influencing factors were identified by logistic regression. Results The micronucleus abnormality rate was 6.05% for the 661 industrial radiation workers. There was no significant difference in micronucleus abnormality rate between sexes (P > 0.05). Comparison of age groups showed that the rate of micronucleus abnormality increased with age, and workers over 50 years of age has the highest rate of micronucleus abnormalities (17.81%); there was a significant difference between age groups (P < 0.05). There was a significant difference in micronucleus abnormality rate between occupational categories (P < 0.05). There was a significant difference in micronucleus abnormality rate between groups with different years of work (P < 0.05). Logistic regression analysis showed that age and years of work were the risk factors for micronucleus abnormality rate (P < 0.05); age was an independent risk factor for micronucleus abnormality rate (P < 0.05). Conclusion The effect of low-dose ionizing radiation on micronucleus abnormality rate of industrial radiation workers is related to age and working years. Attention should be paid to occupational health monitoring of radiation workers, especially those with advanced age.
  • Dose conversion coefficients for humans after oral administration of urea-14C
    ZHANG Zhen, TANG Guangyi, MA Zhongjian, ZHU Weiguo, CHEN Fei
    2024, 33(2): 153-157. https://doi.org/10.13491/j.issn.1004-714X.2024.02.008
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    Objective To calculate the absorbed doses and conversion coefficients of various organs in humans after oral administration of urea-14C, and to provide a convenient method for evaluating the internal radiation dose caused by ingestion of urea-14C in Chinese population. Methods The Chinese reference human voxel model was imported into the FLUKA software to simulate the absorbed doses to organs under internal exposure to 14C, and to obtain the dose conversion coefficients for oral administration of urea-14C. Results The absorbed dose conversion coefficients for the stomach, colon, bladder, heart, and muscles were 0.029, 0.029, 0.32 (0.24), 0.028, and 0.029 mGy/MBq in negative cases, and 0.079, 0.078, 0.18 (0.15), 0.076, and 0.080 mGy/MBq in positive cases. The committed effective dose coefficients were 0.041 (0.037) mSv/MBq in negative cases and 0.082 (0.081) mSv/MBq in positive cases. Conclusion The dose conversion coefficients obtained in this study can provide important parameters for evaluating the absorbed dose to Chinese population after oral administration of urea-14C.
  • Development of a mobile personnel radiation protection equipment
    HE Yuan, PANG Hongchao, LIU Yang, WU Jianhua, WANG Junlin, HONG Yanan, CHEN Xubiao, WANG Hualin, SHI Xiaoyu, PAN Miao, WANG Qiang
    2024, 33(2): 158-163. https://doi.org/10.13491/j.issn.1004-714X.2024.02.009
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    Objective To design a mobile personnel radiation protection equipment for operation in environments with high radiation such as spent fuel reprocessing plants, to achieve simultaneous protection against γ radiation, neutron radiation, and radioactive aerosol, to reduce the internal and external exposure dose of radioactive workers, and to meet the requirement of operation for two hours. Methods The core parts of the mobile personnel radiation protection equipment included a shielding chamber and a respiratory maintenance system. An automated chassis was used for the movement and lifting of the shielding chamber. MCNP software was used to simulate and calculate the protective effects of shielding chamber made of different materials and material thicknesses. Experimental verification of the shielding chamber design was conducted. Mathematical models were established to describe the variations in the content of various gases in the chamber with personnel operation time. A respiratory maintenance system, a harmful gas absorption device, and an automated mobile chassis were designed. Results The shielding chamber made of polyethylene with a thickness of 80 mm achieved an 80% neutron shielding rate. The respiratory maintenance system could support workers for 2 hours of operation inside the equipment. The mobile chassis allowed operation of the equipment with one person. Conclusion This mobile personnel radiation protection equipment can solve the problem in simultaneous protection against γ radiation, neutron radiation, and radioactive aerosol. The equipment can provide radiation protection for radioactive workers, reduce exposure dose, and reduce personnel burden. This system provides technical means for the operation and maintenance of equipment in high-radiation sites such as spent fuel reprocessing plants.
  • Verification of a method for determination of tritiated water in ambient air
    DING Hongshen, LIU Wenna, ZHAO Wanbing, ZHENG Lin, ZHANG Xuqin, LIU Weidong, YU Xianchen
    2024, 33(2): 164-169. https://doi.org/10.13491/j.issn.1004-714X.2024.02.010
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    Objective To experimentally verify the precision and accuracy of determining tritiated water in ambient air using the desiccant adsorption sampling–high temperature negative pressure desorption of liquid water (containing HTO)–liquid Scintillation counter method, and to provide technical support for developing standard methods for monitoring tritiated water in ambient air. Methods The relative standard deviation and recovery of multi-group samples were verified by collecting, testing, and analyzing environmental samples with different activity concentrations. The uncertainty of the method was evaluated, the main uncertainty components were identified, and the reliability of measurement results was analyzed. Through experimental comparison of different methods, the differences in the test results of different methods were examined. Results The relative standard deviation of multiple samples ranged from 6.7% to 7.9%, the recovery ranged from 95.7% to 97.3%, and the uncertainty was greatly affected by the sample counting rate, with no significant difference as compared to condensation sampling method. Conclusion The precision and accuracy of this method meet the requirements of environmental authorities for monitoring tritiated water in ambient air, and it can be widely used in the monitoring of tritiated water in ambient air.
  • Analysis of the frequency of therapy-oriented oral radiation in Nanping, China
    LI Chaohui, ZHANG Yuanhao, TAN Jiahua, XU Zhiyuan, WANG Jun, WANG Jieqiong, YOU Chenwen, LIU Bin, QIU Lili, DENG Jun
    2024, 33(2): 170-175. https://doi.org/10.13491/j.issn.1004-714X.2024.02.011
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    Objective To investigate the frequency of therapy-oriented oral radiation in Nanping, China and its distribution, and to provide a basis for the rational application of therapy-oriented oral radiation and the effective allocation of resources in Nanping. Methods A questionnaire was designed to investigate the frequency of therapy-oriented oral radiation in all oral radiation diagnosis and treatment institutions in Nanping. Results In 2021, there were 54 oral radiation diagnosis and treatment institutions and 79 oral radiation machines in Nanping. The total frequency of therapy-oriented oral radiation was 61593 visits and the radiation frequency was 19.54 visits per thousand patients. The average annual frequency of medical institutions at all levels was 721.87 to 3713.25 visits per institution; the male-to-female composition ratio of frequency of therapy-oriented oral radiation in December 2021 was 50.5%:49.5%. The proportion of radiation frequency of different devices was as follows: 38.7% (intraoral dental film), 46.5% (oral panorama), 10.3% (oral computed tomography [CT]), and 4.5% (cranial photography). The proportion of radiation frequency in patients of different ages was as follows: 17.1% (0-15 years), 48.2% (15-40 years), and 34.7% (over 40 years). The frequency of therapy-oriented oral radiation grew by 77.43%, 35.18%, and 8.16% every two years from 2015 to 2021, respectively. Conclusion The frequency level of therapy-oriented oral radiation in Nanping is at the level of Class II health care. The distribution of therapy-oriented oral radiation is highly unbalanced and is related to the level of economic development. Private healthcare institutions are growing rapidly, and public healthcare institutions of grade two and above occupy the main healthcare resources. The oral panorama accounts for the most, cranial photography accounts for the least, and oral CT is the fastest-growing portion. Therapy-oriented oral radiation is predominantly performed in the young and middle-aged populations, regardless of sex. Except for intraoral dental films, the general trend is upward.
  • Background radioactivity levels of gross α and gross β in foods around Zhangzhou nuclear power plant, China
    LIU Jia, LIU Mengmeng, ZHENG Qishan, LV Jirong, QING Yunhua, ZHANG Yan, LIN Dan, HUANG Lihua
    2024, 33(2): 176-182. https://doi.org/10.13491/j.issn.1004-714X.2024.02.012
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    Objective To investigate the radioactivity levels of gross α and gross β in foods around Zhangzhou nuclear power plant, China before operation. Methods Forty-nine samples from 33 kinds of foods in 5 categories of daily food around Zhangzhou nuclear power plant were collected, pretreated, dried, and ashed. The radioactivity levels of gross α and gross β were measured by the low-background α and β measuring instrument. The atomic absorption technique was employed to measure the level of potassium (K), and the radioactivity level of gross β (subtracting 40K) was calculated with K concentrations in different foods consulted from the nutritional dietary system. Results The radioactivity levels of gross α in vegetables and fruits, grain, poultry and livestock, aquatic products, and tea around Zhangzhou nuclear power plant were < minimum detectable level (MDL)-7.97, < MDL-6.82, < MDL, < MDL-20.76, and 11.90-23.08 Bq/kg, respectively; the radioactivity levels of gross β were 34.56-122.81, 13.05-188.96, 56.00-108.34, 17.86-169.01, and 123.74-171.63 Bq/kg, respectively; the radioactivity levels of gross β (subtracting 40K) were not detected (ND)-14.27, ND-27.86, ND-48.72, ND-45.85, and 6.69-13.79 Bq/kg, respectively. Conclusion The radioactivity of gross α and gross β in foods around Zhangzhou nuclear power plant before operation is basically at the same level as that in other areas of China.
  • Influence of geometric factor on detection efficiency in low-background α/β radioactivity measurement
    LI Xiaoshuang, LIU Jiayu
    2024, 33(2): 183-188,202. https://doi.org/10.13491/j.issn.1004-714X.2024.02.013
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    Objective To study the influence of the radius of the active zone of the plane source and the horizontal distance between the source center and the center of the detection window on the detection efficiency of low-background α/β measuring instruments. Methods The geometric factor was calculated under different conditions in MATLAB, and a traceable plane source was used to test and analyze two commonly used measuring instruments. Results With the other parameters unchanged, when the radius of the active zone R1 = 9 mm, the G value was greatest; and when the horizontal distance a = 0 mm, the G value was greatest. According to the calculation formula of the verification regulation, for the 90Sr-90Y planar source, at the maximum value of a, the detection efficiency of FYFS-400X was 1.2% lower, and that of MPC-9604 was 3.2% lower; for the 241Am planar source, the detection efficiency of MPC-9604 was 1.9% lower at the maximum value of a. Conclusion The geometric factor decreases with the increase in the radius of the active zone and the horizontal distance between the source center and the center of the detection window. At the central position, the geometric factor has less influence on the relative standard uncertainty of detection efficiency. When using a standard plane source for counting, measures should be taken to ensure that the plane source is always centrally located in the sample tray.
  • Predictive value of a new radiotherapy plan evaluation tool for bladder toxicity in cervical cancer
    LIU Qingxiao, ZHU Yuexiang, TIAN Long, YANG Songlin, WANG Zheng, ZHAO Yusen, REN Zhiying, CHANG Maoye
    2024, 33(2): 189-194. https://doi.org/10.13491/j.issn.1004-714X.2024.02.014
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    Objective To evaluate the predictive value of a dose-surface histogram (DSH) for radiation cystitis (RC) in patients with cervical cancer. Methods We retrospectively included 190 patients with cervical cancer who underwent image-guided radiotherapy (IGRT) from the HIS system of The First Affiliated Hospital of Hebei North University from May 2013 to May 2023. The patients were divided into test group (n = 100) and control group (n = 90). The dose distribution in the bladder was evaluated by using a DSH for the test group and using a dose-volume histogram (DVH) for the control group. Receiver operating characteristic curves were used to evaluate the predictive value of DSH for RC in comparison with DVH. Results There were no significant differences in baseline data and RC incidence between the two groups (all P＞0.05). All evaluation indicators were significantly different between DSH and DVH (all P＜0.05). The predictive value of S45 and V45 for the incidence of grade-I, -II, and -III RC was low (all P＜0.05). The predictive value of S50 and V50 for the incidence of grade-I, -II, and -III RC was moderate (all P＜0.05). S55-S57 and V55-V57 showed high value for predicting the incidence of grade-I, -II, and -III RC (all P＜0.05). Conclusion DSH shows basically the same predictive value for the incidence of RC caused by IGRT in cervical cancer as DVH, which is expected to become a new tool for evaluating radiotherapy plans.
  • Value of transvaginal ultrasound combined with 3.0T magnetic resonance imaging for the diagnosis of ectopic pregnancy
    LI Jianguo, LI Rong, JIANG Daibin, YANG Lamei, TAN Yan, TU Yuan
    2024, 33(2): 195-199. https://doi.org/10.13491/j.issn.1004-714X.2024.02.015
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    Objective To compare the value of transvaginal ultrasound, 3.0T magnetic resonance imaging (MRI) scanning alone and in combination for diagnosis of ectopic pregnancy, so as to provide insights into early screening of ectopic pregnancy.Methods This study enrolled a total of 130 patients with suspected ectopic pregnancy admitted to Dachuan People’s Hospital in Dazhou City, Sichuan Province, China between February 2019 and December 2022. All patients underwent transvaginal ultrasound examination and 3.0T MRI scanning. The consistency of transvaginal ultrasound and 3.0T MRI with clinical diagnostic results was evaluated with surgical pathology or clinical follow-up results as the golden standards. The sensitivity, specificity, and accuracy of transvaginal ultrasound and 3.0T MRI, alone and in combination, were compared for diagnosis of ectopic pregnancy. Results Of the 130 patients with suspected ectopic pregnancy, 108 cases were confirmed with ectopic pregnancy by surgical pathology, and 22 cases were confirmed without ectopic pregnancy by clinical follow-up. The sensitivity, specificity, and accuracy of transvaginal ultrasound were 85.19% (92/108), 54.55% (12/22), and 80.00% (104/130), respectively, with 0.358 consistency with clinical diagnostic results. The sensitivity, specificity, and accuracy of 3.0T MRI were 92.59% (100/108), 81.81% (18/22), and 90.77% (118/130), respectively, with 0.694 consistency with clinical diagnostic results. The sensitivity, specificity, and accuracy of transvaginal ultrasound combined with 3.0T MRI were 98.15% (106/108), 72.73% (16/22), and 93.85% (122/130), respectively, with 0.764 consistency with clinical diagnostic results. In addition, the sensitivity and accuracy of transvaginal ultrasound combined with 3.0T MRI were significantly higher than transvaginal ultrasound alone for diagnosis of ectopic pregnancy (χ2 = 11.88 and 10.96, both P < 0.01). Conclusion Transvaginal ultrasound combined with 3.0T MRI may provide more diagnostic information for ectopic pregnancy, and is highly consistent with the clinical diagnostic results. In addition, transvaginal ultrasound combined with 3.0T MRI improves the diagnostic sensitivity and accuracy for ectopic pregnancy than transvaginal ultrasound alone.
  • Exposure due to radionuclides in food other than during a nuclear or radiological emergency — Introduction to IAEA Safety Reports Series No. 114
    YANG Baolu, TUO Fei, ZHOU Qiang
    2024, 33(2): 200-202. https://doi.org/10.13491/j.issn.1004-714X.2024.02.016
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    This paper briefly introduces the main content of IAEA Safety Reports Series No. 114. The aim is to further understand the status and development of exposure due to radionuclides in food other than during a nuclear or radiological emergency, as well as to provide references for the revision and improvement of the limited concentration standard of radioactive substances in food in China.
  • Research progress on medical imaging techniques for diagnosis of breast tumors
    TANG Rui
    2024, 33(2): 203-208. https://doi.org/10.13491/j.issn.1004-714X.2024.02.017
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    Breast cancer is the most common malignancy and the fifth leading cause of cancer-associated mortality in the world, which has become a major global health concern with huge economic, social, and disease burdens. Early diagnosis is crucial for effective treatment and favorable prognosis of breast cancer. Medical imaging techniques can provide a variety of clinical information on the morphology, structure, metabolism, and function of tumor tissues in real-time, tissue damage-free, and minimally invasive manners, which have been widely used and hold great value for breast tumor screening and early diagnosis. This review summarizes the advances on the diagnostic value of medical imaging tools for breast tumors, including ultrasonography, computed tomography, magnetic resonance imaging, positron emission tomography/computed tomography, and breast-specific gamma imaging.
  • Research progress on animal models of combined radiation-wound injury
    HAO Ruolin, DOU Guifang, MENG Zhiyun, YE Tong, LI Nanxi, ZHU Xiaoxia, GU Ruolan, WU Zhuona, GAN Hui
    2024, 33(2): 209-214. https://doi.org/10.13491/j.issn.1004-714X.2024.02.018
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    A combined radiation-wound injury refers to a radiation injury combined with a traumatic wound, with the characteristics of repeated ulceration and a long and difficult healing process, which is a focus in the field of research on difficult-to-heal wounds. To research combined radiation-wound injuries, the establishment of animal models is a key part, and appropriate animal models are a guarantee of reliable experimental results. This review summarizes the current research progress on various animal models of combined radiation-wound injuries in terms of radiation types, animal species, and injury types and location, aiming to provide a scientific basis for establishing standardized animal models, studying injury mechanisms, and evaluating prevention and treatment efficacy for combined radiation-wound injuries.
  • Research progress on the diagnostic reference level for CT examination in children
    GAO Tong, WANG Xiaoshan, MA Ya, CHEN Rui, CHEN Yingmin
    2024, 33(2): 215-220. https://doi.org/10.13491/j.issn.1004-714X.2024.02.019
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    Computed tomography (CT) examination may expose patients to a high radiation dose. The reduction of radiation dose in pediatric CT examinations is becoming increasingly important. The diagnostic reference level (DRL) is a practical tool that can achieve optimization of protection and reduce radiation dose in pediatric CT examinations. This article provides a brief summary of the concept, development methods, current situations by country, and issues related to the DRL in pediatric CT examinations, aiming to provide a references for radiation protection optimization in pediatric CT examinations in China.
  • Progress of research on health effects and healthy risk assessment of ionizing radiation
    TANG Bo, LIU Jianwei, DU Chuansheng, SUN Liang, TU Yu
    2024, 33(2): 221-228. https://doi.org/10.13491/j.issn.1004-714X.2024.02.020
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    Occupational exposure to ionizing radiation represents a critical factor contributing to health risks in workplaces. Previous experimental and clinical studies have demonstrated that ionizing radiation affects human health. Therefore, scientific assessment of health risk caused by ionizing radiation and effective protection against ionizing radiation are of great importance to formulate the preventive interventions against occupational exposure to ionizing radiation. This review summarizes the advances in the research on health effects, health risk assessment methods, and protective interventions of ionizing radiation. We call for research on the health effects of low-dose radiation, individual difference, and optimization of preventive strategies. In addition, improved mechanisms of health monitoring, periodical healthy examinations, and monitoring of radiation doses should be implemented. Moreover, strict compliance to operating procedures and occupational preventive interventions are recommended. These measures aim to minimize the potential harmlessness of occupational exposure to ionizing radiation, thereby safeguarding the health and safety of individuals exposed to ionizing radiation.